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Pharmacodynamics I
โฑ 18:34
12/30
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Q12 Agonists
A patient on long-term beta-blocker therapy suddenly stops his medication. He presents 48 hours later with severe rebound hypertension and tachycardia. The pharmacodynamic mechanism responsible is:
A
Tachyphylaxis of cardiac receptors to catecholamines
โœ—
B
Up-regulation of ฮฒ-adrenoceptors now exposed to catecholamines
โœ“
C
Increased catecholamine synthesis in the adrenal medulla
D
Down-regulation of adrenergic receptors throughout the body
๐Ÿ“– Explanation
Chronic antagonist use causes receptor up-regulation โ€” more ฮฒ-receptors are inserted into the membrane. Abrupt withdrawal exposes this increased receptor population to circulating catecholamines, producing a rebound sympathomimetic response. This is why beta-blockers must never be stopped suddenly.
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